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Effect of Lipopolysaccharide (LPS) and Outer Membrane Protein (OMP) Vaccines on Protection of Grass Carp (Ctenopharyngodon idella) against Aeromonas hydrophila
|Title:||Effect of Lipopolysaccharide (LPS) and Outer Membrane Protein (OMP) Vaccines on Protection of Grass Carp (Ctenopharyngodon idella) against Aeromonas hydrophila|
show 1 moreQiao, Xiuting
|LC Subject Headings:||Fish culture--Israel--Periodicals.|
|Publisher:||Israeli Journal of Aquaculture - BAMIGDEH|
|Citation:||Jinhui Sun, Qingkui Wang, Zhiyi Qiao, Dongqing Bai, Jingfeng Sun, Xiuting Qiao. (2011). Effect of Lipopolysaccharide (LPS) and Outer Membrane Protein (OMP) Vaccines on Protection of Grass Carp (Ctenopharyngodon idella) against Aeromonas hydrophila. The Israeli Journal of Aquaculture - Bamidgeh, 63, 8 pp.|
|Series/Report no.:||The Israeli Journal of Aquaculture - Bamidgeh|
|Abstract:||The gram-negative bacterium, Aeromonas hydrophila, causes high mortality and economic losses to the aquaculture industry. We investigated whether lipopolysaccharide (LPS) or outer membrane proteins (OMP) from A. hydrophila can enhance specific and/or non-specific immunity in grass carp (Ctenopharyngodon idella). Fish were injected intraperitoneally with LPS, OMP, or formalin-killed cells (FKC) from A. hydrophila. The control group was injected with phosphate buffered saline (PBS). All three antigens elicited strong immune responses. Respiratory burst and phagocytic activities in head kidney leukocytes and serum lysozyme activity peaked on day 21 after vaccination. Heavy chain gene transcription of immunoglobulin M and Z in the head kidney in vaccinated fish peaked on day 28. Relative percent survival was 83.3%, 72.2%, and 55.6% in the LPS, OMP, and FKC groups, respectively, but only 10% in control fish. Results suggest that LPS and OMP isolated from A. hydrophila can enhance specific immunity, non-specific immunity, and protection against A. hydrophila in fish. Thus, LPS and OMP could be important antigens for development of vaccines to control diseases caused by A. hydrophila in grass carp and other aquatic animals.|
|Appears in Collections:||IJA Volume 63, 2011|
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