Please use this identifier to cite or link to this item: http://hdl.handle.net/10524/53656

Acetaminophen levels 4 and 7 hours after 2000 and 3000 mg single doses in healthy adults.

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Title: Acetaminophen levels 4 and 7 hours after 2000 and 3000 mg single doses in healthy adults.
Authors: Sumida, Shawn M
Sato, Renee L.
Wong, Jeffrey J
Yamamoto, Loren
Issue Date: Jan 2003
Abstract: PURPOSE: Therapeutic acetaminophen levels are not achieved at currently recommended doses. The purpose of this study is to determine acetaminophen levels in healthy adults after taking a single dose well in excess of the recommended dose. METHODS: 24 healthy adults received single 2 or 3 gram acetaminophen doses. Serum acetaminophen levels were drawn at 4 and 7 hours after the dose. RESULTS: The 2 gram doses (6 subjects) ranged from 23 to 40 mg/kg of body weight. The 3 gram single doses (18 subjects) ranged from 38 to 69 mg/kg of body weight. Mean 4-hour acetaminophen levels for 2 and 3 gram doses were 8.8 (SD 3.6, range 3-13) and 21.8 (SD 6.5, range 6-32) mcg/ml, respectively. Mean 7-hour acetaminophen levels for 2 and 3 gram doses were 1.5 (SD 1.4, range 0-3) and 7.7 (SD 4.6, range 0-17) mcg/ml, respectively. CONCLUSIONS: Dosing by weight (i.e., mg/kg) appears to provide a more predictable dose-response relationship. Optimal adult dosing appears to be somewhere in the 20 to 30 mg/kg range based on the premise that the 4 hour level is a trough level that should be in the low therapeutic range.
Sponsor: P20 RR11091/RR/NCRR NIH HHS/United States
URI/DOI: http://hdl.handle.net/10524/53656
ISSN: 0017-8594
Appears in Collections:Hawaii Medical Journal Articles For 2003



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