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Gradual loss of IgG antibodies against GB virus C/hepatitis G virus in a patient with AIDS.

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Title: Gradual loss of IgG antibodies against GB virus C/hepatitis G virus in a patient with AIDS.
Authors: Nerurkar, V R
Chua, P K
Shikuma, Cecilia M.
Dashwood, W M
Milne, C I
show 4 moreWoodward, C L
Kobayashi, G
Peterson, J E
Yanagihara, R

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Issue Date: Dec 1998
Abstract: GB virus C/hepatitis G virus (GBV-C/HGV) is a positive-sense, single-stranded RNA virus belonging to the family Flaviviridae and is distantly related to hepatitis C virus (HCV). GBV-C/HGV can be transmitted by the parenteral and the sexual route. Among individuals infected with human immunodeficiency virus type 1 (HIV-1) by the sexual route, we and others have demonstrated a high prevalence of GBV-C/HGV infection. Recently, Woolley and colleagues reported that AIDS patients co-infected with GBV-C/HGV had a significantly lower mean CD4 cell count than AIDS patients without GBV-C/HGV infection, suggesting that GBV-C/HGV antibody may be lost with progression to AIDS. To our knowledge no data are available on the loss of antibody against GBV-C/HGV in AIDS patients. We now report on an HIV-infected patient who exhibited gradual loss of IgG antibodies against GBV-C/HGV, as well as HCV, with progression of HIV disease.
Sponsor: G12RR/AI-03061/RR/NCRR NIH HHS/United States
ISSN: 0017-8594
Appears in Collections:Hawaii Medical Journal Articles For 1998

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