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Long-term low dose interferon alpha-2b in the treatment of chronic hepatitis B in multi-ethnic patients in Hawaii.

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Title: Long-term low dose interferon alpha-2b in the treatment of chronic hepatitis B in multi-ethnic patients in Hawaii.
Authors: Ching, Nathaniel P. H.
Lumeng, J
Pang, R
Pang, G
Or, F W
show 2 moreChing, Natascha W. H.
Ching, Clara

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Issue Date: Oct 1996
Abstract: The antiviral and immunomodulatory effects of interferon were assessed in the treatment of chronic hepatitis B in multi-ethnic patients to prevent viral replication and chronic liver damage. Five million units of recombinant interferon alpha-2b were administered three times a week for 48 weeks to a group of 18 chronic active hepatitis B patients. A complete response was defined as seroconversion to anti-HBe and/or loss of HBe antigen. Seroconversion to anti-HBe in 5 of 12 (42%) chronic active hepatitis B patients occurred after 48 weeks of therapy. HBV-DNA decreased to undetectable levels in 8 of 12 (67%) patients. This chronic low-dose interferon administration regimen demonstrated responses comparable to other studies.
URI/DOI: http://hdl.handle.net/10524/54086
ISSN: 0017-8594
Appears in Collections:Hawaii Medical Journal Articles For 1996



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