Acetaminophen levels 4 and 7 hours after 2000 and 3000 mg single doses in healthy adults.
Date
2003-01
Contributor
Advisor
Department
Instructor
Depositor
Speaker
Researcher
Consultant
Interviewer
Narrator
Transcriber
Annotator
Journal Title
Journal ISSN
Volume Title
Publisher
Volume
62
Number/Issue
1
Starting Page
Ending Page
Alternative Title
Abstract
PURPOSE: Therapeutic acetaminophen levels are not achieved at currently recommended doses. The purpose of this study is to determine acetaminophen levels in healthy adults after taking a single dose well in excess of the recommended dose. METHODS: 24 healthy adults received single 2 or 3 gram acetaminophen doses. Serum acetaminophen levels were drawn at 4 and 7 hours after the dose. RESULTS: The 2 gram doses (6 subjects) ranged from 23 to 40 mg/kg of body weight. The 3 gram single doses (18 subjects) ranged from 38 to 69 mg/kg of body weight. Mean 4-hour acetaminophen levels for 2 and 3 gram doses were 8.8 (SD 3.6, range 3-13) and 21.8 (SD 6.5, range 6-32) mcg/ml, respectively. Mean 7-hour acetaminophen levels for 2 and 3 gram doses were 1.5 (SD 1.4, range 0-3) and 7.7 (SD 4.6, range 0-17) mcg/ml, respectively. CONCLUSIONS: Dosing by weight (i.e., mg/kg) appears to provide a more predictable dose-response relationship. Optimal adult dosing appears to be somewhere in the 20 to 30 mg/kg range based on the premise that the 4 hour level is a trough level that should be in the low therapeutic range.
Description
Keywords
Citation
Extent
Format
Geographic Location
Time Period
Related To
Related To (URI)
Table of Contents
Rights
Rights Holder
Local Contexts
Collections
Email libraryada-l@lists.hawaii.edu if you need this content in ADA-compliant format.