Effects of chronic heat stress on spleen structure, apoptosis and immune response in Siberian Sturgeon (<em>Acipenser baerii</em>)
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2024
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76
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Chronic heat stress induced by global warming has important implications for fish survival, and the response of important immune organs, such as the spleen, to chronic heat stress remains to be investigated. In this study, one control group (20 ℃) and two heat stress groups (24 ℃ and 28 ℃) were set up to investigate the effects of heat stress on the spleen of Siberian Sturgeon (Acipenser baerii). As per the histological section analysis, heat stress caused vacuolization, reticulocyte hyperplasia, and macrophage infiltration in the spleen, with hyperplasia being more pronounced in the 28 ℃ group. The flow cytometry results showed that the spleen's apoptosis level significantly increased at 28 ℃ (p < 0.05). Hematological studies revealed a significant increase in the number of red blood cells in the 28 ℃ group (p < 0.05). Meanwhile, the mRNA expression of immune-related factors (tgf-β, il-1β, and il-8) was significantly higher in the 28 ℃ heat stress group compared with the control group. This study reveals the effects of heat stress on the A. baerii spleen and contributes to the understanding of coping strategies of cold-water fish to chronic heat stress.
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Acipenser baerii, apoptosis, immune response, spleen
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The Israeli Journal of Aquaculture - Bamidgeh
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