Therapy with hypertonic saline in combination with anti-convulsants for hyponatremia-induced seizure: a case report and review of the literature.

dc.contributor.author Youn, Kristi S M
dc.contributor.author Tokeshi, Jinichi
dc.date.accessioned 2016-10-25T22:59:26Z
dc.date.available 2016-10-25T22:59:26Z
dc.date.issued 2002-12
dc.description.abstract Seizures are an uncommon but serious complication of hyponatremia which can lead to permanent brain damage and even death. It is recommended that patients with hyponatremic-induced seizures be treated with 3% hypertonic saline, however, a rapid rate of correction may result in central pontine myelinolysis (CPM), a severe neurological disorder characterized by mutism, dysarthria, spastic quadriparesis, and pseudobulbar palsy. The patient in this case developed a hyponatremia-induced generalized tonic-clonic seizure which was aborted by rapid therapy with diazepam, followed by hypertonic saline and phenytoin. Subsequent replacement of hypertonic saline with normal saline and salt tabs in combination with phenytoin allowed gradual correction of serum sodium without any subsequent seizures or neurological complications.
dc.identifier.issn 0017-8594
dc.identifier.pubmed 12632826
dc.identifier.uri http://hdl.handle.net/10524/53661
dc.language.iso eng
dc.subject.mesh Aged
dc.subject.mesh Anticonvulsants/therapeutic use
dc.subject.mesh Diazepam/therapeutic use
dc.subject.mesh Drug Therapy, Combination
dc.subject.mesh Epilepsy, Tonic-Clonic/drug therapy/etiology
dc.subject.mesh Female
dc.subject.mesh Humans
dc.subject.mesh Hyponatremia/complications/drug therapy
dc.subject.mesh Phenytoin/therapeutic use
dc.subject.mesh Saline Solution, Hypertonic/therapeutic use
dc.subject.mesh Seizures/drug therapy/etiology
dc.subject.mesh Treatment Outcome
dc.title Therapy with hypertonic saline in combination with anti-convulsants for hyponatremia-induced seizure: a case report and review of the literature.
dc.type Article
dc.type.dcmi Text
prism.number 12
prism.pagerange 280-1
prism.publicationname Hawaii Medical Journal
prism.volume 61
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