Therapy with hypertonic saline in combination with anti-convulsants for hyponatremia-induced seizure: a case report and review of the literature.

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dc.contributor.authorYoun, Kristi S M
dc.contributor.authorTokeshi, Jinichi
dc.date.accessioned2016-10-25T22:59:26Z
dc.date.available2016-10-25T22:59:26Z
dc.date.issued2002-12
dc.description.abstractSeizures are an uncommon but serious complication of hyponatremia which can lead to permanent brain damage and even death. It is recommended that patients with hyponatremic-induced seizures be treated with 3% hypertonic saline, however, a rapid rate of correction may result in central pontine myelinolysis (CPM), a severe neurological disorder characterized by mutism, dysarthria, spastic quadriparesis, and pseudobulbar palsy. The patient in this case developed a hyponatremia-induced generalized tonic-clonic seizure which was aborted by rapid therapy with diazepam, followed by hypertonic saline and phenytoin. Subsequent replacement of hypertonic saline with normal saline and salt tabs in combination with phenytoin allowed gradual correction of serum sodium without any subsequent seizures or neurological complications.
dc.identifier.issn0017-8594
dc.identifier.pubmed12632826
dc.identifier.urihttp://hdl.handle.net/10524/53661
dc.language.isoeng
dc.subject.meshAged
dc.subject.meshAnticonvulsants/therapeutic use
dc.subject.meshDiazepam/therapeutic use
dc.subject.meshDrug Therapy, Combination
dc.subject.meshEpilepsy, Tonic-Clonic/drug therapy/etiology
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshHyponatremia/complications/drug therapy
dc.subject.meshPhenytoin/therapeutic use
dc.subject.meshSaline Solution, Hypertonic/therapeutic use
dc.subject.meshSeizures/drug therapy/etiology
dc.subject.meshTreatment Outcome
dc.titleTherapy with hypertonic saline in combination with anti-convulsants for hyponatremia-induced seizure: a case report and review of the literature.
dc.typeArticle
dc.type.dcmiText
prism.number12
prism.pagerange280-1
prism.publicationnameHawaii Medical Journal
prism.volume61

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