Substituting dietary fishmeal with soybean meal isolate influences hepatic lipid metabolism and gut microbiota in spotted seabass (<em>Lateolabrax maculatus</em>)

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dc.contributor.authorWang, Zhe
dc.contributor.authorYang, Linkun
dc.contributor.authorZhang, Chunxiao
dc.contributor.authorWang, Ling
dc.contributor.authorLu, Kangle
dc.contributor.authorSong, Kai
dc.date.accessioned2021-11-02T18:00:54Z
dc.date.available2021-11-02T18:00:54Z
dc.date.issued2021
dc.description.abstractThis study was conducted to investigate the effects of partial substitution of dietary fishmeal (FM) by soy protein isolate (SPI) on lipid metabolism and gut microbiota of spotted seabass. A diet containing 30% FM formed the basal diet (FM), and two SPI diets were formulated in which 25% (SPI25) and 50% (SPI50) of FM were replaced by SPI. Each diet was fed to triplicates of fish for 56 days. The results showed that replacing dietary FM with SPI reduced triglyceride and cholesterol contents in the liver and serum, and the hepatic lipid droplets area was also decreased by dietary SPI inclusion. Furthermore, replacement of dietary FM with SPI markedly down-regulated the mRNA expression of genes involved in lipogenesis (srebpc-1c, fas, acc1, hmgcr, pparĪ³ and chrebp) and lipolysis (atgl, hsl, pparĪ±, and cpt1). Moreover, high-throughput sequencing analyses of gut microbiota revealed that dietary SPI inclusion dramatically decreased the Firmicutes/Bacteroidetes ratio. Overall, this study indicated that replacing 25-50% of dietary FM with SPI could reduce lipid accumulation in serum and liver of spotted seabass, which was associated with the suppressed hepatic lipogenesis and the remodeled gut microbiota.
dc.format.extent13 pages
dc.identifier.doihttps://doi.org/10.46989/001c.29803
dc.identifier.issn0792-156X
dc.identifier.urihttp://hdl.handle.net/10524/64103
dc.relation.ispartofThe Israeli Journal of Aquaculture - Bamidgeh
dc.subjectsoy protein isolate
dc.subjectfishmeal replacement
dc.subjectlipid metabolism
dc.subjectgut microbiota
dc.subjectspotted seabass
dc.subjectfishmeal
dc.titleSubstituting dietary fishmeal with soybean meal isolate influences hepatic lipid metabolism and gut microbiota in spotted seabass (<em>Lateolabrax maculatus</em>)
dc.typeArticle
dc.type.dcmiText
prism.volume73

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Volume 73, 2021