Dietary Supplementation of Glycyrrhetinic Acid (GA) Promoting Lipid Lipolysis from Blunt Snout Bream Megalobrama amblycephala by TNF-α and LPL Expression

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dc.contributor.authorLiu, M-y
dc.contributor.authorLiu, G-x.
dc.contributor.authorZhou, M.
dc.contributor.authorLiu, W-b.
dc.contributor.authorJiang, G.
dc.date.accessioned2019-01-08T20:43:31Z
dc.date.available2019-01-08T20:43:31Z
dc.date.issued2018
dc.description.abstractGlycyrrhetinic acid (GA), which is a main active principal constituent of liquorice, is extensively used as a non-nutrition sweetener or antiinflammatory in Chinese medicine. This study was carried out to evaluate the effects of different GA levels on growth, biometric parameters, plasma lipid metabolites, Tumor necrosis factor alpha (TNF-α) and Lipoprotein lipase (LPL) gene expression of Megalobrama amblycephala (average weight, 68.78 ±1.13 g). Three diets were formulated to contain various levels of GA (0, 30 and 300 mg/kg). Fish were randomly distributed into 12 cages and fed three times daily for 8 weeks. Dietary GA levels have little significant effect on weight gain and feed conversion ratio. Intraperitoneal fat ratio and viscera/body ratio decreased significantly as dietary GA levels increased, and hepatosomatic index tended to decrease as dietary GA levels increased. Plasma triglycerides, cholesterol, and non-esterified free fatty acid levels also decreased as dietary GA concentrations increased. Adipose tissue and liver TNF-α expression increased significantly with increasing dietary GA levels; whereas, LPL expression showed an opposite trend. Results of this study indicate that dietary supplementation of 300 mg/kg GA had a positive effect in promoting lipid lipolysis in Megalobrama amblycephala without having a negative effect on growth through the regulation of TNF-α and LPL expression.
dc.format.extent8 pages
dc.identifier.issn0792-156X
dc.identifier.urihttp://hdl.handle.net/10524/59395
dc.subjectMegalobrama amblycephala
dc.subjectGlycyrrhetinic acid
dc.subjecttumor necrosis factor
dc.subjectLipoprotein lipase
dc.subjectgene expression
dc.subjectfat tissue mass
dc.subject.lcshFish culture--Israel.
dc.subject.lcshFish culture
dc.titleDietary Supplementation of Glycyrrhetinic Acid (GA) Promoting Lipid Lipolysis from Blunt Snout Bream Megalobrama amblycephala by TNF-α and LPL Expression
dc.typeArticle
dc.type.dcmiText

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Volume 70, 2018