Erythromycin-induced resistance to clindamycin in Staphylococcus aureus.

dc.contributor.author Marr, Jonathan K
dc.contributor.author Lim, Audrey T
dc.contributor.author Yamamoto, Loren
dc.date.accessioned 2016-10-25T22:44:23Z
dc.date.available 2016-10-25T22:44:23Z
dc.date.issued 2005-01
dc.description.abstract PURPOSE: To describe the incidence of erythromycin-induced resistance to clindamycin in a sample of Staphylococcus aureus isolates. METHODS: 100 erythromycin-resistant and clindamycin-sensitive S. aureus were collected as a convenience sample from February to August 2003. Inducible clindamycin resistance was identified using the D-zone disc method. RESULTS: Of the 100 Staphylococcus aureus isolates, 64 were methicillin sensitive (MSSA) and 36 were methicillin resistant (MRSA). Of the 64 MSSA isolates, 22 (34%) had inducible resistance. Of the 36 MRSA isolates, 4 (11%) had inducible resistance. Overall, 26% of these clindamycin sensitive S. aureus isolates, exhibited inducible resistance to clindamycin. CONCLUSIONS: In this sample, MSSA isolates were almost three times more likely to have inducible MLS resistance compared to MRSA isolates. Inducible resistance may compromise the efficacy of clindamycin. The frequency of inducible resistance in this series of "clindamycin sensitive" S. aureus isolates is 26%. It is likely that the true percentage of clindamycin resistance is being underestimated since testing for inducible resistance is not routinely performed.
dc.identifier.issn 0017-8594
dc.identifier.pubmed 15751751
dc.identifier.uri http://hdl.handle.net/10524/53491
dc.language.iso eng
dc.subject.mesh Anti-Bacterial Agents/pharmacology
dc.subject.mesh Clindamycin/pharmacology
dc.subject.mesh Drug Resistance, Bacterial
dc.subject.mesh Erythromycin/pharmacology
dc.subject.mesh Humans
dc.subject.mesh Methicillin/pharmacology
dc.subject.mesh Methicillin Resistance
dc.subject.mesh Microbial Sensitivity Tests
dc.subject.mesh Staphylococcus aureus/drug effects/isolation & purification
dc.title Erythromycin-induced resistance to clindamycin in Staphylococcus aureus.
dc.type Article
dc.type.dcmi Text
prism.number 1
prism.pagerange 6-8
prism.publicationname Hawaii Medical Journal
prism.volume 64
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