The immunologic staging of chronic active hepatitis B patients in Hawaii.

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dc.contributor.authorChing, N
dc.contributor.authorLumeng, J
dc.contributor.authorPon, E
dc.contributor.authorChing, C Y
dc.date.accessioned2019-07-02T16:05:59Z
dc.date.available2019-07-02T16:05:59Z
dc.date.issued1994-02
dc.description.abstractThe hepatitis B antigen/antibody levels and natural killer cell activity status of chronic hepatitis B patients identified by the Hawaii State Department of Health were evaluated to select chronically infected hepatitis B patients for interferon therapy and to determine possible immunodeficiencies. The presence of hepatitis Be antigen denotes active replication of the virus. Ninety-five patients were studied: 17/95 (18%) had chronic active hepatitis B, 71/95 (75%) were hepatitis B carriers and 7/95 (7%) had seroconverted. NK activity to the erythroleukemia K562 cell and virus-infected HSV-1 cell of the chronic active and carrier population (P < .05) were lower than that of the control population and those who had spontaneously seroconverted. Of this population 18% were identified with active viral infection and would be candidates for interferon therapy.
dc.identifier.issn0017-8594
dc.identifier.pubmed7514583
dc.identifier.urihttp://hdl.handle.net/10524/62525
dc.language.isoeng
dc.subject.meshAdult
dc.subject.meshCell Line
dc.subject.meshFemale
dc.subject.meshHawaii
dc.subject.meshHepatitis B/diagnosis/immunology/therapy
dc.subject.meshHepatitis B Antibodies/immunology
dc.subject.meshHepatitis B Antigens/immunology
dc.subject.meshHepatitis, Chronic/diagnosis/immunology/therapy
dc.subject.meshHumans
dc.subject.meshInterferons/therapeutic use
dc.subject.meshKiller Cells, Natural/immunology
dc.subject.meshMale
dc.titleThe immunologic staging of chronic active hepatitis B patients in Hawaii.
dc.typeJournal Article
dc.type.dcmiText
prism.number2
prism.pagerange44-5, 49
prism.publicationnameHawaii medical journal
prism.volume53

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