Research Progress in Molecular Biology of Fish Immunoglobulin M (IgM)

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dc.contributor.authorXia, Hu
dc.contributor.authorLu, Juanjuan
dc.contributor.authorYang, Pinhong
dc.contributor.authorChen, Fuyan
dc.contributor.authorZhang, Yunsheng
dc.contributor.authorLiu, Laiangguo
dc.contributor.authorChen, Zhongyuan
dc.contributor.authorHuang, Ruyu
dc.date.accessioned2023-03-29T00:44:19Z
dc.date.available2023-03-29T00:44:19Z
dc.date.issued2023
dc.description.abstractImmunoglobulin (Ig) is a type of globulin produced by B lymphocytes during pathogenic infection of vertebrates. It has immune functions and can realize specific recognition and neutralization of corresponding antigens. As IgM is reported first in fish, IgM is the first antibody produced during immune responses and plays a vital role in systemic and mucosal immune tissues. IgM molecules have two forms: membrane-bound IgM (mIgM) and secreted IgM (sIgM). The latter is produced by plasmacytes and secreted into body fluid, existing as immunological effect molecules. The former embeds into B cytomembrane and exists as an antigen receptor. It binds with assistant molecules to form cell receptor compounds. This study reviews research progress on the structures and production processes of IgM genes in different fish species and the distribution characteristics of IgM on B cells, mediated signal pathways, and functions. It aims to enrich basic theoretical knowledge of fish immunology and provide some scientific references for disease control in fishes.
dc.format.extent7 pages
dc.identifier.doihttps://doi.org/10.46989/001c.73925
dc.identifier.issn0792-156X
dc.identifier.urihttps://hdl.handle.net/10524/69425
dc.relation.ispartofThe Israeli Journal of Aquaculture - Bamidgeh
dc.subjectimmunoglobulin M
dc.subjectimmune response
dc.subjectsignal pathways
dc.subjectteleost
dc.titleResearch Progress in Molecular Biology of Fish Immunoglobulin M (IgM)
dc.typeArticle
dc.type.dcmiText
prism.volume75

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Volume 75, Issue 1, 2023