Quercetin inhibits largemouth bass rhabdovirus infection by enhancing the immune response in <em>Micropterus salmoides</em>

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dc.contributor.authorXue, Mingyang
dc.contributor.authorJiang, Yangyang
dc.contributor.authorXu, Chen
dc.contributor.authorHuang, Zhenyu
dc.contributor.authorJiang, Nan
dc.contributor.authorLi, Yiqun
dc.contributor.authorMeng, Yan
dc.contributor.authorFan, Yuding
dc.contributor.authorZhou, Yong
dc.date.accessioned2025-03-28T20:50:59Z
dc.date.available2025-03-28T20:50:59Z
dc.date.issued2025
dc.description.abstractThe Largemouth bass Rhabdovirus (LMBRaV) is a highly virulent pathogen that results in substantial mortality rates and economic losses within the largemouth bass (<em>Micropterus salmoides</em>) aquaculture industry. The utilization of medicinal plant extracts has emerged as a promising strategy for combating aquatic animal diseases. In this study, we aimed to evaluate the anti-LMBRaV properties effects of nine plant-derived compounds utilizing EPC cells and largemouth bass. Among them, quercetin demonstrated a notable inhibitory effect on LMBRaV replication in EPC, with a reduction of 93.6% at 20 mg/L. Quercetin exerts its anti-LMBRaV properties on cells may result from its ability to inhibit viral entry, mitigate nuclear damage, and inactivate the virus directly. <em>In vivo</em> experiments showed that the preventive protection rate of quercetin against LMBRaV infection in largemouth bass reached 57.7%, and decreased LMBRaV viral loads in liver, spleen and kidney. Moreover, quercetin appeared to induce the expression of several immune-related genes, including interferon (IFN), and major histocompatibility complex 1 (MHC-1), myxovirus resistance 1 (MX1), and nuclear factor erythroid 2-related factor 2 (Nrf2), suggesting its potential for immunoregulation. Furthermore, quercetin mitigated the pathological alterations in the immune organs of largemouth bass infected with LMBRaV. In summary, quercetin shows promise as an immunomodulatory agent against LMBRaV infections in largemouth bass.
dc.identifier.doihttps://doi.org/10.46989/001c.128997
dc.identifier.issn0792-156X
dc.identifier.urihttps://hdl.handle.net/10524/81420
dc.relation.ispartofThe Israeli Journal of Aquaculture - Bamidgeh
dc.subjectAntivirals
dc.subjectlargemouth bass rhabdovirus (LMBRaV)
dc.subjectQuercetin
dc.subjectImmunomodulator
dc.subjectMicropterus salmoides
dc.titleQuercetin inhibits largemouth bass rhabdovirus infection by enhancing the immune response in <em>Micropterus salmoides</em>
dc.typeArticle
dc.type.dcmiText
prism.volume77

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Volume 77, Issue 1, 2025